The original question was "Is the 25-06 with a 117 gr Sierra adequate for a 300 yd shot on a deer"
IMO, very adequate.
My understanding from the beginning was you have a second plane scope.
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So if you sight in at 200 yards with the first dot below the crosshair at 9 power, then increase the magnification to 12 power and use the same first dot, the impact point will not be the same.
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I agree with this statement.
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At 200 yards I increase the target size so that the crosshair blocks all the central white so I know I'm centered. At 300 I do the same thing but use the first ballistic dot to obliterate the white central enlarged dot.
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This may be where I misinterpreted your statement . I assumed you were doing this with the variable ring. As I reread it.maybe you posted different size targets downrange.
Oh well. I have no clue why the deer ran off. Maybe you clipped a blade of grass.