I feel fortunate that I have never had to deal with a Very Large Something with Lots Of Teeth. However, it occurs to me that if I had reasonable expectation to do so, I would practice shooting from the hip--or other awkward postition--and in doing so quite rapidly. And accurately, of course.
Shotgun with slugs, .45-70 Guide Gun sort of critter, semi-auto in '06 or better...Something you can put into action very, very quickly and having lots of "Thump!".
What you don't have, from what I have read, is a lot of time to think about what to do. Sorta like dealing with a very hostile Street Ape, only worse.
Art
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