The issues that come to my mind with leaving a gun in a car are:
1) security of the firearm and
2) degradation of the ammunition.
I would argue that a vehicle is not a desirable place to store a weapon. I am unable to find authoritative information, but I would guess that a significant percentage of firearms are stolen from vehicles. It is simple and quick to smash a window, search a vehicle and steal whatever is available. I think it would be prudent to invest in some device which would slow the thief.
Secondly, I would think that temperatures over 120 degrees Fahrenheit would accelerate the decay of the powder and/or the primer of the ammunition. Instead of a useful life on the order of decades it might be shortened to just a few years. No biggie if you shoot the ammo before it goes bad.
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NRA Life Member - Orange Gunsite Member - NRA Certified Pistol Instructor
"When plunder becomes a way of life for a group of men living together in society,
they create for themselves in the course of time a legal system that authorizes it and a moral code that justifies it." Frederic Bastiat