Aim for the neck
Steady clean neck shot, you bet. Will drop it in its tracks, which is important if you have a hard time getting around on your prosthetic legs (no tracking). In fact, there's probably few better rounds for neck shots on deer. Hit it dead center of the neck.
Vitals shot, NO, it's quite marginal - use something bigger - even a .223 with 60+ grain soft point or ballistic tip would be better than an exploding .22-250 bullet for a vitals shot - not ethical unless you're 1,000% sure you're missing the legs/shoulder blades and going into the vitals dead-on broadside. We've discussed .22-250 at length for deer in the hunting forum. Castnblast has used it successfully for deer. Bullet selection is more important than caliber if you must try this. Use at least a 55 grain soft point, IMO - not a varmint round - no hollowpoints.
But ideally, grab at least a .44 mag, .30-30 win, or .243 win, to minimize chance of wounding.
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