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I taken several deer out to 200 yards with .223 in a mini 14 and a colt ar. I taken a few with a 22-250. I going to try a m1 carbine this year. I have never had to shoot more than one time. As long as it's legal to use in your area I feel bullet placement has more to do with a clean kill more than the size of the round. The farthest any deer has traveled for me was one I did have to track for about a half mile that I'd hit solidly with a 265 grain soft point from a .444 that was hit in the lungs from a distance of 40 yards.
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