Oddly enough, I was having a discussion on this very topic with a female coworker this afternoon. I had seen the Homeboy Nightsights before, and told her about them. She laughed her butt off, just like I (and all of you) have also done.
I've never tried shooting like that, but I believe it could be done (and done well) with some practice. The only real change I see would be placing the front sight to the right of the target (or to the left if you happen to be left-handed) in your sight picture.
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