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I suspect bullet construction was a major contributor here. The old standby CoreLokt tends to expand, and lose energy faster than many of the more modern designs. (I don't see that as a problem. It is my favorite bullet in several calibers.)
Another factor could be the weight you were using. 100 grain bullets, although common, typically have trouble stabilizing in many .243s. If the bullet was unstable, it could have been tumbling before hitting the animal; or destabilized when it hit... causing extreme loss of energy.
As for my experience - I have only shot one pronghorn antelope with the .243 Winchester. Serious penetration, major tissue damage, no exit. I was using a 100 grain Winchester Power Point, but it is a similar design to the CoreLokt. (And, a bullet I will never use again; after discovering how inconsistently they are constructed.)
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