Ahem, well, I expect a .500 Jeffery would be adequate...with expanding bullets.
To answer the original question of the thread, I would vote for a load of #2 lead shot, like one would use for turkey. One shot to the head, repeat if required. Less edible meat damage.
The hides worth anything? My Luchese smooth ostrich skin ropers are my favorite boots
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With top loads & hard cast bullets, a .357 mag, .41 mag, .44 special, .44 mag, .45 Colt, .454 Casull, .475 Linebaugh, .480 Ruger, .500 Linebaugh Maximum, and .500 S&W will all shoot through Bison. To select the gun, determine how big a hole you want to put in the Bison, and how much recoil you can stand
