In your situation I'd focus on neck shots. For that the super 22's will do fine.
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Personally I won't use anything smaller than a .308.
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The .22-250 is longer than the .308 I believe. I assume you mean .30 caliber. With modern bullet design bigger does not always mean better, not that I have a problem with your choice. I feel that the quarter bore up to the .30 cals occupy the sweet spot for deer and similar game for most shots (raking and other).