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IMHO, the best caliber is whatever you can afford and can shoot proficiently.
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What are the criteria and minimum acceptable performance for those? How do they balance against each other. For example, I believe most skilled shooters would have high proficiency with a 22LR and it is $3-$5 per 50 vs a 44 mag which many would have medium to low proficiency and $70 per 50. So we should all get 22’s?
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The most important factor though is an operator of said firearm that can place shots into an assailant accurately under a high stress situation. A calm, resolute, good marksman with a .22 is more dangerous than a hysterical, person that never trains with their gun and has a 9mm or .45.
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Is this another vote for 22?
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So my question is: With what pistol/caliber are you most likely to hit what you intend to hit?
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22LR definitely.
I’m not really picking at this, people to consider the balance between practical accuracy, shot-to-shot speed and bullet performance.
To me those are what gun/cartridge can I shoot 0.33s or better splits, place all shots on a paper plate at 7 yds and is the best bullet performance I’ll carry. Obviously cost of ownership keeps some rounds out of there.