I carry Hornady 180gr JHP's. I did a lot of research before choosing a round, and the 180gr. do perform better in close quarters. You don't have to worry about your round potentially making it through your intended target, and into something else behind it. The heavier rounds are also slower and "hit" harder than the lighter, faster rounds. Ask the US army about the stopping power of ammo.
They used to use .45 Long colt, and decided to try out the lighter, faster .38 Long Colt (Phillipine Rebellion of 1899), but after almost losing the battle, they decided to go back to the .45 Long Colt. It all boils down to stopping power.
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